calc vacs 2 derived

{
  "input": {
    "body": {
      "items": [
        {
          "age": 40,
          "fib4": 1,
          "bmi_kg_m2": 26,
          "wbc_10e9_l": 6,
          "hepatitis_c": false,
          "albumin_g_dl": 4.2,
          "cd4_cells_mm3": 600,
          "hemoglobin_g_dl": 15,
          "hiv_rna_copies_ml": 50,
          "egfr_ml_min_1_73m2": 100
        },
        {
          "age": 40,
          "fib4": 1,
          "bmi_kg_m2": 26,
          "wbc_10e9_l": 6,
          "hepatitis_c": false,
          "albumin_g_dl": 4.2,
          "cd4_cells_mm3": 600,
          "hemoglobin_g_dl": 15,
          "hiv_rna_copies_ml": 50,
          "egfr_ml_min_1_73m2": 100
        }
      ]
    },
    "type": "http",
    "method": "POST"
  },
  "output": {
    "type": "json",
    "example": {
      "path": "/api/calc/vacs_2",
      "count": 2,
      "items": [
        {
          "age": 40,
          "fib4": 1,
          "score": 30,
          "formula": "vacs_2",
          "citation": {
            "id": "tate-2019-vacs-2",
            "doi": "10.1097/QAD.0000000000002140",
            "pmid": "30649088",
            "title": "Albumin, white blood cell count, and body mass index improve discrimination of mortality in HIV-positive individuals",
            "source": "AIDS. 2019;33(5):903-912",
            "authors": "Tate JP, Sterne JAC, Justice AC; Veterans Aging Cohort Study (VACS) and the Antiretroviral Therapy Cohort Collaboration (ART-CC)"
          },
          "bmi_kg_m2": 26,
          "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
          "wbc_10e9_l": 6,
          "hepatitis_c": false,
          "albumin_g_dl": 4.2,
          "cd4_cells_mm3": 600,
          "hemoglobin_g_dl": 15,
          "linear_predictor": -1.428513,
          "hiv_rna_copies_ml": 50,
          "egfr_ml_min_1_73m2": 100,
          "formula_expression": "lp = age_poly + cd4_poly + rna_poly + hb_poly + fib4_poly + egfr_spline + hcv + alb_poly + wbc_poly + bmi_poly; score = round(44 + 20*(lp - lp_median)); lp_median is Appendix Table 2 median profile (age 52, CD4 435, log10 HIV-1 RNA 1.7, Hb 14, FIB-4 1.34, eGFR 90, HCV no, albumin 4, WBC 5.5, BMI 25.3); age censored 30-75, X=(age-50)/5, PE 0.056/-0.004/0.005; CD4 censored 0-1000 as ln(max(1000-CD4, 1)), PE -0.056/-0.153/0.024; HIV-1 RNA log10 copies censored 1.3-5.0, centered (logVL-2), PE 0.513/-0.422/0.098; hemoglobin censored 9-16, centered (hemoglobin-14), PE -0.134/0.026/0.005; FIB-4 censored 0.5-7.5, PE 0.220/-0.009; eGFR censored 0-180, X1=eGFR/10, X2=max(eGFR-35,0)/10, X3=max(eGFR-65,0)/10, X4=max(eGFR-115,0)/10, PE -0.031/-0.077/0.106/0.133; HCV yes 0.342; albumin censored 2-5, centered (albumin-4), PE -0.443/0.104/0.028; WBC 10^9/L censored 2.5-11, centered (WBC-5.5), PE 0.126/0.020/-0.004; BMI censored 15-35, centered (BMI-25), PE -0.055/0.004; Tate 2019 Appendix Table 1 main analysis LVCF 180 days; caller-assigned FIB-4 and eGFR; not VACS 1.0; no published S0"
        },
        {
          "age": 40,
          "fib4": 1,
          "score": 30,
          "formula": "vacs_2",
          "citation": {
            "id": "tate-2019-vacs-2",
            "doi": "10.1097/QAD.0000000000002140",
            "pmid": "30649088",
            "title": "Albumin, white blood cell count, and body mass index improve discrimination of mortality in HIV-positive individuals",
            "source": "AIDS. 2019;33(5):903-912",
            "authors": "Tate JP, Sterne JAC, Justice AC; Veterans Aging Cohort Study (VACS) and the Antiretroviral Therapy Cohort Collaboration (ART-CC)"
          },
          "bmi_kg_m2": 26,
          "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
          "wbc_10e9_l": 6,
          "hepatitis_c": false,
          "albumin_g_dl": 4.2,
          "cd4_cells_mm3": 600,
          "hemoglobin_g_dl": 15,
          "linear_predictor": -1.428513,
          "hiv_rna_copies_ml": 50,
          "egfr_ml_min_1_73m2": 100,
          "formula_expression": "lp = age_poly + cd4_poly + rna_poly + hb_poly + fib4_poly + egfr_spline + hcv + alb_poly + wbc_poly + bmi_poly; score = round(44 + 20*(lp - lp_median)); lp_median is Appendix Table 2 median profile (age 52, CD4 435, log10 HIV-1 RNA 1.7, Hb 14, FIB-4 1.34, eGFR 90, HCV no, albumin 4, WBC 5.5, BMI 25.3); age censored 30-75, X=(age-50)/5, PE 0.056/-0.004/0.005; CD4 censored 0-1000 as ln(max(1000-CD4, 1)), PE -0.056/-0.153/0.024; HIV-1 RNA log10 copies censored 1.3-5.0, centered (logVL-2), PE 0.513/-0.422/0.098; hemoglobin censored 9-16, centered (hemoglobin-14), PE -0.134/0.026/0.005; FIB-4 censored 0.5-7.5, PE 0.220/-0.009; eGFR censored 0-180, X1=eGFR/10, X2=max(eGFR-35,0)/10, X3=max(eGFR-65,0)/10, X4=max(eGFR-115,0)/10, PE -0.031/-0.077/0.106/0.133; HCV yes 0.342; albumin censored 2-5, centered (albumin-4), PE -0.443/0.104/0.028; WBC 10^9/L censored 2.5-11, centered (WBC-5.5), PE 0.126/0.020/-0.004; BMI censored 15-35, centered (BMI-25), PE -0.055/0.004; Tate 2019 Appendix Table 1 main analysis LVCF 180 days; caller-assigned FIB-4 and eGFR; not VACS 1.0; no published S0"
        }
      ]
    }
  }
}