calc score2 op derived

{
  "input": {
    "body": {
      "items": [
        {
          "age": 75,
          "sex": "male",
          "smoker": true,
          "diabetes": false,
          "sbp_mm_hg": 150,
          "non_hdl_mmol_l": 4.5,
          "european_risk_region": "low"
        },
        {
          "age": 75,
          "sex": "male",
          "smoker": true,
          "diabetes": false,
          "sbp_mm_hg": 150,
          "non_hdl_mmol_l": 4.5,
          "european_risk_region": "low"
        }
      ]
    },
    "type": "http",
    "method": "POST"
  },
  "output": {
    "type": "json",
    "example": {
      "path": "/api/calc/score2_op",
      "count": 2,
      "items": [
        {
          "age": 75,
          "sex": "male",
          "smoker": true,
          "formula": "score2_op",
          "citation": {
            "id": "score2-op-2021",
            "doi": "10.1093/eurheartj/ehab312",
            "pmid": "34120185",
            "title": "SCORE2-OP risk prediction algorithms: estimating incident cardiovascular event risk in older persons in four geographical risk regions",
            "source": "Eur Heart J. 2021;42(25):2455-2467",
            "authors": "SCORE2-OP working group and ESC Cardiovascular risk collaboration"
          },
          "diabetes": false,
          "sbp_mm_hg": 150,
          "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
          "hdl_mmol_l": 1.4,
          "non_hdl_mmol_l": 4.5,
          "linear_predictor": 0.4181,
          "risk_10y_percent": 22.5,
          "formula_expression": "10-year fatal+non-fatal CVD % = 100*(1-exp(-exp(scale1+scale2*ln(-ln(1-uncal))))); uncal=1-S0^exp(lp); cage=age-73; csbp=(SBP-150)/10; charts display non-HDL mmol/L; equation uses TC and HDL at paper HDL centering 1.4 so TC=non-HDL+1.4, ctc=TC-6, chdl=0; diabetes is included (not SCORE2-Diabetes); men S0=0.7576 lp=0.063*cage+0.425*diabetes-0.017*cage*diabetes+0.352*smoke-0.025*cage*smoke+0.094*csbp-0.005*cage*csbp+0.085*ctc+0.007*cage*ctc-0.356*chdl+0.009*cage*chdl; women S0=0.8082 lp=0.079*cage+0.601*diabetes-0.011*cage*diabetes+0.492*smoke-0.026*cage*smoke+0.102*csbp-0.004*cage*csbp+0.060*ctc-0.001*cage*ctc-0.304*chdl+0.015*cage*chdl; region (scale1,scale2) men low (-0.3400,1.1900) moderate (0.0100,1.2500) high (0.0800,1.1500) very_high (0.0500,0.7000); women low (-0.5200,1.0100) moderate (-0.1000,1.1000) high (0.3800,1.0900) very_high (0.3800,0.6900); SCORE2-OP 2021 Table 2 coefficients and supplement four-decimal scale1/scale2 and baseline survival; age 70-89; geographic region not race; not SCORE2; not SCORE2-Diabetes; not 2013 PCE; not PREVENT",
          "european_risk_region": "low",
          "total_cholesterol_mmol_l": 5.9
        },
        {
          "age": 75,
          "sex": "male",
          "smoker": true,
          "formula": "score2_op",
          "citation": {
            "id": "score2-op-2021",
            "doi": "10.1093/eurheartj/ehab312",
            "pmid": "34120185",
            "title": "SCORE2-OP risk prediction algorithms: estimating incident cardiovascular event risk in older persons in four geographical risk regions",
            "source": "Eur Heart J. 2021;42(25):2455-2467",
            "authors": "SCORE2-OP working group and ESC Cardiovascular risk collaboration"
          },
          "diabetes": false,
          "sbp_mm_hg": 150,
          "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
          "hdl_mmol_l": 1.4,
          "non_hdl_mmol_l": 4.5,
          "linear_predictor": 0.4181,
          "risk_10y_percent": 22.5,
          "formula_expression": "10-year fatal+non-fatal CVD % = 100*(1-exp(-exp(scale1+scale2*ln(-ln(1-uncal))))); uncal=1-S0^exp(lp); cage=age-73; csbp=(SBP-150)/10; charts display non-HDL mmol/L; equation uses TC and HDL at paper HDL centering 1.4 so TC=non-HDL+1.4, ctc=TC-6, chdl=0; diabetes is included (not SCORE2-Diabetes); men S0=0.7576 lp=0.063*cage+0.425*diabetes-0.017*cage*diabetes+0.352*smoke-0.025*cage*smoke+0.094*csbp-0.005*cage*csbp+0.085*ctc+0.007*cage*ctc-0.356*chdl+0.009*cage*chdl; women S0=0.8082 lp=0.079*cage+0.601*diabetes-0.011*cage*diabetes+0.492*smoke-0.026*cage*smoke+0.102*csbp-0.004*cage*csbp+0.060*ctc-0.001*cage*ctc-0.304*chdl+0.015*cage*chdl; region (scale1,scale2) men low (-0.3400,1.1900) moderate (0.0100,1.2500) high (0.0800,1.1500) very_high (0.0500,0.7000); women low (-0.5200,1.0100) moderate (-0.1000,1.1000) high (0.3800,1.0900) very_high (0.3800,0.6900); SCORE2-OP 2021 Table 2 coefficients and supplement four-decimal scale1/scale2 and baseline survival; age 70-89; geographic region not race; not SCORE2; not SCORE2-Diabetes; not 2013 PCE; not PREVENT",
          "european_risk_region": "low",
          "total_cholesterol_mmol_l": 5.9
        }
      ]
    }
  }
}