{"api":"v1","generated_at":"2026-10-01T02:39:18.635Z","licence":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/","attribution":"TOLL, with a link to the page cited"},"page":"https://tollindex.com/e/api-magentlab-com-api-calc-mcdonald-2024-17ffb2","pinned_page":"https://tollindex.com/e/api-magentlab-com-api-calc-mcdonald-2024-17ffb2/at/2026-09-30T22-14Z","pinned":false,"method":"https://tollindex.com/ledger/method","snapshot_at":"2026-09-30T22:14:11.940Z","snapshot_stamp":"2026-09-30T22-14Z","endpoint":{"slug":"api-magentlab-com-api-calc-mcdonald-2024-17ffb2","canonical_url":"https://api.magentlab.com/api/calc/mcdonald_2024","resource":"https://api.magentlab.com/api/calc/mcdonald_2024","http_method":"POST","type":"http","x402_version":2,"registries":["cdp"],"primary_registry":"cdp","curated_by_coinbase":false,"description":"2024 McDonald typical CIS (Montalban 2025). mcdonald_ms iff typical_cis and no_better_explanation and: ≥2 attacks with ≥2 lesions; or ≥2 attacks with one lesion plus DIS; or CIS with ≥2 lesions plus MRI DIT, OCB, or kappa FLC; or CIS with one lesion plus DIS and MRI DIT, OCB, or kappa FLC. DIS = ≥2 of 5 topographies (optic nerve added). Kappa FLC interchangeable with OCB. Not 2017 McDonald. Not PPMS. Not RIS. magent does not read MRI or assay CSF. Not a diagnosis. Not a medical device.","service_name":"magent","declared_category":null,"declared_tags":["mcdonald-2024","multiple-sclerosis","neurology","cis","calculator"],"route_template":null,"registry_updated":"2026-09-28T15:01:45.725Z"},"derived":{"note":"fields no registry supplies; TOLL derives them and marks them derived on the page","title":"calc mcdonald 2024","category":"other","first_observed_by_toll":"2026-09-28T13:51:25.436Z","last_observed_by_toll":"2026-09-30T22:14:11.940Z","observation_began":"2026-09-10"},"presence":{"listed_now":true,"first_absent_at":null,"delisting_confirmed_at":null,"events":[{"registry":"cdp","at":"2026-09-28T13:51:25.437Z","event":"listed"}]},"accepts":[{"registry":"cdp","ordinal":0,"network":"eip155:8453","asset":"0x833589fcd6edb6e08f4c7c32d4f71b54bda02913","asset_name":"USD Coin","symbol":"USDC","decimals":6,"amount_display":"0.005 USDC","amount_units":0.005,"decimals_known":true,"pay_to":"0x836Be278f1739fB4308091cD1852F7971Bc19Ee2","scheme":"exact"}],"counters":{"observed_at":"2026-09-30T22:14:11.940Z","calls_30d":2,"unique_payers_30d":1,"last_called_at":"2026-09-28T15:01:45.587Z"},"validation":{"latest":{"observed_at":"2026-09-30T05:54:49.146Z","state":"pass","failed_checks":[],"endpoint_http_status":402,"run_id":"daily-2026-09-30"},"uptime":[{"days":7,"observed":4,"passed":4,"ratio":1},{"days":30,"observed":4,"passed":4,"ratio":1},{"days":90,"observed":4,"passed":4,"ratio":1}],"history_90d":[{"observed_at":"2026-09-30T05:54:49.146Z","state":"pass","failed_checks":[],"run_id":"daily-2026-09-30","state_changed":false},{"observed_at":"2026-09-29T18:15:44.695Z","state":"pass","failed_checks":[],"run_id":"daily-2026-09-29","state_changed":false},{"observed_at":"2026-09-28T16:52:58.887Z","state":"pass","failed_checks":[],"run_id":"daily-2026-09-28","state_changed":false},{"observed_at":"2026-09-28T15:07:21.830Z","state":"pass","failed_checks":[],"run_id":"new-after-daily-2026-09-28","state_changed":true}]},"seller":{"wallet":"0x836Be278f1739fB4308091cD1852F7971Bc19Ee2","page":"https://tollindex.com/seller/0x836Be278f1739fB4308091cD1852F7971Bc19Ee2","endpoints":844,"hosts":1},"reports":0,"registry_record":{"cdp":[{"tags":["mcdonald-2024","multiple-sclerosis","neurology","cis","calculator"],"type":"http","accepts":[{"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","extra":{"name":"USD Coin","version":"2","paymentFlow":"upfront","resourceUrl":"https://api.magentlab.com/api/calc/mcdonald_2024","assetTransferMethod":"eip3009"},"payTo":"0x836Be278f1739fB4308091cD1852F7971Bc19Ee2","amount":"5000","scheme":"exact","network":"eip155:8453","maxTimeoutSeconds":600}],"quality":{"lastCalledAt":"2026-09-28T15:01:45.587Z","l30DaysTotalCalls":2,"l30DaysUniquePayers":1},"resource":"https://api.magentlab.com/api/calc/mcdonald_2024","extensions":{"bazaar":{"info":{"input":{"body":{"items":[{"dit_mri":false,"csf_kflc":false,"optic_nerve":false,"spinal_cord":false,"typical_cis":true,"infratentorial":false,"periventricular":false,"csf_specific_ocb":false,"two_or_more_attacks":true,"two_or_more_lesions":true,"no_better_explanation":true,"cortical_or_juxtacortical":false},{"dit_mri":false,"csf_kflc":false,"optic_nerve":false,"spinal_cord":false,"typical_cis":true,"infratentorial":false,"periventricular":false,"csf_specific_ocb":false,"two_or_more_attacks":true,"two_or_more_lesions":true,"no_better_explanation":true,"cortical_or_juxtacortical":false}]},"type":"http","method":"POST"},"output":{"type":"json","example":{"path":"/api/calc/mcdonald_2024","count":2,"items":[{"dis":false,"dit_mri":false,"formula":"mcdonald_2024","citation":{"id":"montalban-2025","doi":"10.1016/S1474-4422(25)00270-4","pmid":"40975101","title":"Diagnosis of multiple sclerosis: 2024 revisions of the McDonald criteria","source":"Lancet Neurol. 2025;24(10):850-865","authors":"Montalban X, Lebrun-Frénay C, Oh J, et al."},"criteria":[{"met":true,"factor":"typical_cis"},{"met":true,"factor":"no_better_explanation"},{"met":true,"factor":"two_or_more_attacks"},{"met":true,"factor":"two_or_more_lesions"},{"met":false,"factor":"periventricular"},{"met":false,"factor":"cortical_or_juxtacortical"},{"met":false,"factor":"infratentorial"},{"met":false,"factor":"spinal_cord"},{"met":false,"factor":"optic_nerve"},{"met":false,"factor":"dis"},{"met":false,"factor":"dit_mri"},{"met":false,"factor":"csf_specific_ocb"},{"met":false,"factor":"csf_kflc"},{"met":true,"factor":"relapsing_cis_pathway"},{"met":true,"factor":"mcdonald_ms"}],"csf_kflc":false,"disclaimer":"Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.","mcdonald_ms":true,"optic_nerve":false,"spinal_cord":false,"typical_cis":true,"infratentorial":false,"periventricular":false,"csf_specific_ocb":false,"formula_expression":"mcdonald_ms iff typical_cis and no_better_explanation and ((two_or_more_attacks and two_or_more_lesions) or (two_or_more_attacks and not two_or_more_lesions and dis) or (not two_or_more_attacks and two_or_more_lesions and (dit_mri or csf_specific_ocb or csf_kflc)) or (not two_or_more_attacks and not two_or_more_lesions and dis and (dit_mri or csf_specific_ocb or csf_kflc))) (Montalban 2025 / 2024 McDonald typical CIS). dis is true iff at least two of periventricular, cortical_or_juxtacortical, infratentorial, spinal_cord, optic_nerve are true. CSF kappa free-light chains are interchangeable with CSF-specific OCB as the CSF DIT substitute. Not PPMS. Not RIS. Not 2017 McDonald. magent does not read MRI, OCT, VEP, or assay CSF. Not a diagnosis","two_or_more_attacks":true,"two_or_more_lesions":true,"no_better_explanation":true,"cortical_or_juxtacortical":false},{"dis":false,"dit_mri":false,"formula":"mcdonald_2024","citation":{"id":"montalban-2025","doi":"10.1016/S1474-4422(25)00270-4","pmid":"40975101","title":"Diagnosis of multiple sclerosis: 2024 revisions of the McDonald criteria","source":"Lancet Neurol. 2025;24(10):850-865","authors":"Montalban X, Lebrun-Frénay C, Oh J, et al."},"criteria":[{"met":true,"factor":"typical_cis"},{"met":true,"factor":"no_better_explanation"},{"met":true,"factor":"two_or_more_attacks"},{"met":true,"factor":"two_or_more_lesions"},{"met":false,"factor":"periventricular"},{"met":false,"factor":"cortical_or_juxtacortical"},{"met":false,"factor":"infratentorial"},{"met":false,"factor":"spinal_cord"},{"met":false,"factor":"optic_nerve"},{"met":false,"factor":"dis"},{"met":false,"factor":"dit_mri"},{"met":false,"factor":"csf_specific_ocb"},{"met":false,"factor":"csf_kflc"},{"met":true,"factor":"relapsing_cis_pathway"},{"met":true,"factor":"mcdonald_ms"}],"csf_kflc":false,"disclaimer":"Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.","mcdonald_ms":true,"optic_nerve":false,"spinal_cord":false,"typical_cis":true,"infratentorial":false,"periventricular":false,"csf_specific_ocb":false,"formula_expression":"mcdonald_ms iff typical_cis and no_better_explanation and ((two_or_more_attacks and two_or_more_lesions) or (two_or_more_attacks and not two_or_more_lesions and dis) or (not two_or_more_attacks and two_or_more_lesions and (dit_mri or csf_specific_ocb or csf_kflc)) or (not two_or_more_attacks and not two_or_more_lesions and dis and (dit_mri or csf_specific_ocb or csf_kflc))) (Montalban 2025 / 2024 McDonald typical CIS). dis is true iff at least two of periventricular, cortical_or_juxtacortical, infratentorial, spinal_cord, optic_nerve are true. CSF kappa free-light chains are interchangeable with CSF-specific OCB as the CSF DIT substitute. Not PPMS. Not RIS. Not 2017 McDonald. magent does not read MRI, OCT, VEP, or assay CSF. Not a diagnosis","two_or_more_attacks":true,"two_or_more_lesions":true,"no_better_explanation":true,"cortical_or_juxtacortical":false}]}},"iconUrl":"https://api.magentlab.com/favicon.ico"},"schema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"body":{"type":"object","required":["items"],"properties":{"items":{"type":"array","items":{"type":"object","required":["typical_cis","no_better_explanation","two_or_more_attacks","two_or_more_lesions","periventricular","cortical_or_juxtacortical","infratentorial","spinal_cord","optic_nerve","dit_mri","csf_specific_ocb","csf_kflc"],"properties":{"dit_mri":{"type":"boolean","description":"MRI dissemination in time as assigned by the caller (simultaneous Gd-enhancing and non-enhancing lesions, or a new T2 or Gd-enhancing lesion on follow-up vs baseline). true or false. magent does not read MRI."},"csf_kflc":{"type":"boolean","description":"CSF kappa free-light chains positive as assigned by the caller (2024: interchangeable with oligoclonal bands as the CSF DIT marker). Caller-assigned flag only; this tool does not apply a numeric kFLC index cutoff. true or false. magent does not assay CSF."},"optic_nerve":{"type":"boolean","description":"Caller-assigned typical optic-nerve topography (fifth 2024 DIS location; Montalban 2025). true or false. magent does not read MRI, OCT, or VEP."},"spinal_cord":{"type":"boolean","description":"Caller-assigned typical spinal-cord MS lesion topography (one of five 2024 DIS locations). true or false. magent does not read MRI."},"typical_cis":{"type":"boolean","description":"Typical clinically isolated syndrome as assigned by the caller (Montalban 2025 typical CIS / relapsing pathway). If false, mcdonald_ms is false; this tool does not diagnose MS from atypical presentations, PPMS, or RIS. true or false. magent does not examine the patient."},"infratentorial":{"type":"boolean","description":"Caller-assigned typical infratentorial MS lesion topography (one of five 2024 DIS locations). true or false. magent does not read MRI."},"periventricular":{"type":"boolean","description":"Caller-assigned typical periventricular MS lesion topography (one of five 2024 DIS locations). true or false. magent does not read MRI."},"csf_specific_ocb":{"type":"boolean","description":"CSF-specific oligoclonal bands as assigned by the caller (2024 DIT substitute; interchangeable with kappa free-light chains). true or false. magent does not assay CSF."},"two_or_more_attacks":{"type":"boolean","description":"≥2 clinical attacks as assigned by the caller. true means two or more attacks; false means this is the first/CIS attack. true or false. magent does not date attacks."},"two_or_more_lesions":{"type":"boolean","description":"Objective clinical evidence of ≥2 lesions as assigned by the caller. true means ≥2 lesions; false means 1 lesion. true or false. magent does not examine the patient."},"no_better_explanation":{"type":"boolean","description":"No better explanation for the presentation as assigned by the caller (Montalban 2025). If false, mcdonald_ms is false. Remain vigilant for NMOSD. true or false. magent does not assign a better explanation."},"cortical_or_juxtacortical":{"type":"boolean","description":"Caller-assigned typical cortical or juxtacortical MS lesion topography (one of five 2024 DIS locations). true or false. magent does not read MRI."}}},"maxItems":25,"minItems":1}},"additionalProperties":false},"type":{"type":"string","const":"http"},"method":{"type":"string","const":"POST"},"headers":{"type":"object","additionalProperties":{"type":"string"}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}}}},"description":"2024 McDonald typical CIS (Montalban 2025). mcdonald_ms iff typical_cis and no_better_explanation and: ≥2 attacks with ≥2 lesions; or ≥2 attacks with one lesion plus DIS; or CIS with ≥2 lesions plus MRI DIT, OCB, or kappa FLC; or CIS with one lesion plus DIS and MRI DIT, OCB, or kappa FLC. DIS = ≥2 of 5 topographies (optic nerve added). Kappa FLC interchangeable with OCB. Not 2017 McDonald. Not PPMS. Not RIS. magent does not read MRI or assay CSF. Not a diagnosis. Not a medical device.","lastUpdated":"2026-09-28T15:01:45.725Z","serviceName":"magent","x402Version":2}]}}