{"api":"v1","generated_at":"2026-10-02T07:46:28.039Z","licence":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/","attribution":"TOLL, with a link to the page cited"},"page":"https://tollindex.com/e/api-magentlab-com-api-calc-iwg2-ad-d9a2b9","pinned_page":"https://tollindex.com/e/api-magentlab-com-api-calc-iwg2-ad-d9a2b9/at/2026-10-02T05-34Z","pinned":false,"method":"https://tollindex.com/ledger/method","snapshot_at":"2026-10-02T05:34:29.993Z","snapshot_stamp":"2026-10-02T05-34Z","endpoint":{"slug":"api-magentlab-com-api-calc-iwg2-ad-d9a2b9","canonical_url":"https://api.magentlab.com/api/calc/iwg2_ad","resource":"https://api.magentlab.com/api/calc/iwg2_ad","http_method":"POST","type":"http","x402_version":2,"registries":["cdp"],"primary_registry":"cdp","curated_by_coinbase":false,"description":"Dubois 2014 IWG-2 typical AD research criteria. typical_ad iff early hippocampal-type episodic memory, no better explanation, and in-vivo AD pathology (CSF Abeta1-42 plus T-tau or P-tau, amyloid PET, or a PSEN1/PSEN2/APP mutation). Typical AD only; not atypical phenotypes. Not NINCDS-ADRDA, not NIA-AA ATN, not DSM. magent does not examine the patient, assay CSF, or read PET. Not a diagnosis or medical device.","service_name":"magent","declared_category":null,"declared_tags":["iwg2-ad","alzheimer","neurology","dementia","calculator"],"route_template":null,"registry_updated":"2026-09-28T15:04:42.254Z"},"derived":{"note":"fields no registry supplies; TOLL derives them and marks them derived on the page","title":"calc iwg2 ad","category":"other","first_observed_by_toll":"2026-09-28T13:51:25.436Z","last_observed_by_toll":"2026-10-02T05:34:29.993Z","observation_began":"2026-09-10"},"presence":{"listed_now":true,"first_absent_at":null,"delisting_confirmed_at":null,"events":[{"registry":"cdp","at":"2026-09-28T13:51:25.437Z","event":"listed"}]},"accepts":[{"registry":"cdp","ordinal":0,"network":"eip155:8453","asset":"0x833589fcd6edb6e08f4c7c32d4f71b54bda02913","asset_name":"USD Coin","symbol":"USDC","decimals":6,"amount_display":"0.005 USDC","amount_units":0.005,"decimals_known":true,"pay_to":"0x836Be278f1739fB4308091cD1852F7971Bc19Ee2","scheme":"exact"}],"counters":{"observed_at":"2026-10-02T05:34:29.993Z","calls_30d":3,"unique_payers_30d":1,"last_called_at":"2026-09-28T15:04:42.117Z"},"validation":{"latest":{"observed_at":"2026-10-01T09:36:49.279Z","state":"pass","failed_checks":[],"endpoint_http_status":402,"run_id":"daily-2026-10-01"},"uptime":[{"days":7,"observed":4,"passed":4,"ratio":1},{"days":30,"observed":4,"passed":4,"ratio":1},{"days":90,"observed":4,"passed":4,"ratio":1}],"history_90d":[{"observed_at":"2026-10-01T09:36:49.279Z","state":"pass","failed_checks":[],"run_id":"daily-2026-10-01","state_changed":false},{"observed_at":"2026-09-30T09:04:39.491Z","state":"pass","failed_checks":[],"run_id":"daily-2026-09-30","state_changed":false},{"observed_at":"2026-09-29T21:09:52.177Z","state":"pass","failed_checks":[],"run_id":"daily-2026-09-29","state_changed":false},{"observed_at":"2026-09-28T16:49:37.112Z","state":"pass","failed_checks":[],"run_id":"new-after-daily-2026-09-28","state_changed":true}]},"seller":{"wallet":"0x836Be278f1739fB4308091cD1852F7971Bc19Ee2","page":"https://tollindex.com/seller/0x836Be278f1739fB4308091cD1852F7971Bc19Ee2","endpoints":844,"hosts":1},"reports":0,"registry_record":{"cdp":[{"tags":["iwg2-ad","alzheimer","neurology","dementia","calculator"],"type":"http","accepts":[{"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","extra":{"name":"USD Coin","version":"2","paymentFlow":"upfront","resourceUrl":"https://api.magentlab.com/api/calc/iwg2_ad","assetTransferMethod":"eip3009"},"payTo":"0x836Be278f1739fB4308091cD1852F7971Bc19Ee2","amount":"5000","scheme":"exact","network":"eip155:8453","maxTimeoutSeconds":600}],"quality":{"lastCalledAt":"2026-09-28T15:04:42.117Z","l30DaysTotalCalls":3,"l30DaysUniquePayers":1},"resource":"https://api.magentlab.com/api/calc/iwg2_ad","extensions":{"bazaar":{"info":{"input":{"body":{"items":[{"amyloid_pet":false,"csf_abeta_and_tau":true,"early_episodic_memory":true,"no_better_explanation":true,"autosomal_dominant_mutation":false},{"amyloid_pet":false,"csf_abeta_and_tau":true,"early_episodic_memory":true,"no_better_explanation":true,"autosomal_dominant_mutation":false}]},"type":"http","method":"POST"},"output":{"type":"json","example":{"path":"/api/calc/iwg2_ad","count":2,"items":[{"formula":"iwg2_ad","citation":{"id":"dubois-2014","doi":"10.1016/S1474-4422(14)70090-0","pmid":"24849861","title":"Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria","source":"Lancet Neurol. 2014;13(6):614-629","authors":"Dubois B, Feldman HH, Jacova C, Hampel H, Molinuevo JL, Blennow K, DeKosky ST, Gauthier S, Selkoe D, Bateman R, Cappa S, Crutch S, Engelborghs S, Frisoni GB, Fox NC, Galasko D, Habert MO, Jicha GA, Nordberg A, Pasquier F, Rabinovici G, Robert P, Rowe C, Salloway S, Sarazin M, Epelbaum S, de Souza LC, Vellas B, Visser PJ, Schneider L, Stern Y, Scheltens P, Cummings JL"},"criteria":[{"met":true,"factor":"early_episodic_memory"},{"met":true,"factor":"csf_abeta_and_tau"},{"met":false,"factor":"amyloid_pet"},{"met":false,"factor":"autosomal_dominant_mutation"},{"met":true,"factor":"no_better_explanation"},{"met":true,"factor":"in_vivo_pathology"}],"disclaimer":"Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.","typical_ad":true,"in_vivo_pathology":true,"formula_expression":"typical_ad iff no_better_explanation AND early_episodic_memory AND (csf_abeta_and_tau OR amyloid_pet OR autosomal_dominant_mutation) (Dubois 2014 IWG-2 typical AD). Not NINCDS-ADRDA. Not NIA-AA. Not DSM. magent does not examine the patient or assay CSF/PET."},{"formula":"iwg2_ad","citation":{"id":"dubois-2014","doi":"10.1016/S1474-4422(14)70090-0","pmid":"24849861","title":"Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria","source":"Lancet Neurol. 2014;13(6):614-629","authors":"Dubois B, Feldman HH, Jacova C, Hampel H, Molinuevo JL, Blennow K, DeKosky ST, Gauthier S, Selkoe D, Bateman R, Cappa S, Crutch S, Engelborghs S, Frisoni GB, Fox NC, Galasko D, Habert MO, Jicha GA, Nordberg A, Pasquier F, Rabinovici G, Robert P, Rowe C, Salloway S, Sarazin M, Epelbaum S, de Souza LC, Vellas B, Visser PJ, Schneider L, Stern Y, Scheltens P, Cummings JL"},"criteria":[{"met":true,"factor":"early_episodic_memory"},{"met":true,"factor":"csf_abeta_and_tau"},{"met":false,"factor":"amyloid_pet"},{"met":false,"factor":"autosomal_dominant_mutation"},{"met":true,"factor":"no_better_explanation"},{"met":true,"factor":"in_vivo_pathology"}],"disclaimer":"Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.","typical_ad":true,"in_vivo_pathology":true,"formula_expression":"typical_ad iff no_better_explanation AND early_episodic_memory AND (csf_abeta_and_tau OR amyloid_pet OR autosomal_dominant_mutation) (Dubois 2014 IWG-2 typical AD). Not NINCDS-ADRDA. Not NIA-AA. Not DSM. magent does not examine the patient or assay CSF/PET."}]}},"iconUrl":"https://api.magentlab.com/favicon.ico"},"schema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"body":{"type":"object","required":["items"],"properties":{"items":{"type":"array","items":{"type":"object","required":["early_episodic_memory","csf_abeta_and_tau","amyloid_pet","autosomal_dominant_mutation","no_better_explanation"],"properties":{"amyloid_pet":{"type":"boolean","description":"Increased tracer retention on amyloid PET, as assigned by the caller (Dubois 2014 IWG-2 in-vivo AD pathology). true or false. magent does not read PET."},"csf_abeta_and_tau":{"type":"boolean","description":"Decreased Aβ1-42 together with increased T-tau or P-tau in CSF, as assigned by the caller (Dubois 2014 IWG-2 in-vivo AD pathology). true or false. magent does not assay CSF."},"early_episodic_memory":{"type":"boolean","description":"Early and significant episodic memory impairment of the hippocampal type (IWG-2 specific phenotype for typical AD), as assigned by the caller. true or false. magent does not examine the patient."},"no_better_explanation":{"type":"boolean","description":"Exclusion of other disorders that could account for the phenotype, as assigned by the caller (Dubois 2014 IWG-2). true or false. magent does not examine the patient."},"autosomal_dominant_mutation":{"type":"boolean","description":"Proven AD autosomal-dominant mutation in PSEN1, PSEN2, or APP, as assigned by the caller (Dubois 2014 IWG-2 in-vivo AD pathology). true or false. magent does not sequence genes."}}},"maxItems":25,"minItems":1}},"additionalProperties":false},"type":{"type":"string","const":"http"},"method":{"type":"string","const":"POST"},"headers":{"type":"object","additionalProperties":{"type":"string"}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}}}},"description":"Dubois 2014 IWG-2 typical AD research criteria. typical_ad iff early hippocampal-type episodic memory, no better explanation, and in-vivo AD pathology (CSF Abeta1-42 plus T-tau or P-tau, amyloid PET, or a PSEN1/PSEN2/APP mutation). Typical AD only; not atypical phenotypes. Not NINCDS-ADRDA, not NIA-AA ATN, not DSM. magent does not examine the patient, assay CSF, or read PET. Not a diagnosis or medical device.","lastUpdated":"2026-09-28T15:04:42.254Z","serviceName":"magent","x402Version":2}]}}